Syracuse got on the board first, but would trail Eastern Michigan until 8:13 remaining in the first half, where senior forward James Southerland would connect on his first basket of the game, giving the Orange a 14-12 advantage.
The Orange would never look back from there, getting out to an 18-point lead at the break.
Syracuse continued making history with their 26th-straight win at the Carrier Dome, by the score of 84-48.
Freshman center DaJuan Coleman led all scorers for the Orange with 14. Five Syracuse players ended the game in double-figures.
Sophomore guard Michael Carter-Williams continued his streak of nine or more assists in a game with 11.