The team was coming off of a 4-8 campaign, following a dismal era under Greg Robinson, where the team never advanced to the bowl season.
At the end of the 2010 season, Marrone had helped guide the Orange to a 7-5 record, and the newly-instituted New Era Pinstripe Bowl came calling.
The opponent was the Kansas State Wildcats of the Big 12 Conference.
In front of a highly-dominant Orange crowd, the inaugural Pinstripe Bowl kicked off inside the walls of the new Yankee Stadium.
Kansas State was the first to score, off of a 51-yard rush by running back Daniel Thomas, only to be equaled by Syracuse after a 52-yard hookup between quarterback Ryan Nassib and wide receiver Marcus Sales.
The second quarter was no different, with the Wildcats and Orange matching each other once again. Nassib connected with Sales on their second touchdown play, this of 36 yards, and Thomas ran in another for Kansas State, from 10 yards away.
At the break, the first Pinstripe Bowl stood even at 14-all.
Syracuse was the first to win a quarter, attaining two touchdowns in the third quarter to Kansas State's one; running back Delone Carter ran in both scores for the Orange while Wildcats' quarterback Carson Coffman found wide receiver Chris Harper for their score. But, the Orange missed their extra point attempt on the second touchdown, meaning a touchdown for the Wildcats would give them the lead, with the score 27-21.
Kansas State achieved exactly that, scoring first in the fourth quarter on Thomas' third touchdown of the game.
Nassib took the advantage back for Syracuse finding Sales for their third touchdown, putting the Orange up 33-28.
Syracuse kicker Ross Krautman would add a field goal to the team's lead, making it 36-28 with about three minutes remaining.
Kansas State would take their final possession over the threshold on Coffman's connection with wide receiver Adrian Hilburn for a 30-yard touchdown that brought the Wildcats within two, 36-34.
But Hilburn's salute after his score was flagged for unsportsmanlike conduct, resulting in a 15-yard penalty, sending Kansas State's two-point conversion attempt back to the Syracuse 17-yard line.
The Wildcats failed to convert, and the Orange hoisted the first-ever Pinstripe Bowl trophy, giving Marrone his best season as Syracuse's head coach with an 8-5 closing record in 2010.