The Syracuse Orange formally held the longest active NCAA Division I men's basketball streak of consecutive home wins at 38, dating back to the end of the 2010-11 season.
Louisville took the lead early when junior guard Russ Smith connected on long range on the Cardinals' first possession. He would end perched atop all Cardinals with 18 points on 5-for-11 shooting.
From there, the lead would change hands 12 times, but it would end in the palms of Louisville. Junior guard/forward Luke Hancock's three with 53 seconds to go gave the Cardinals the advantage for good.
After starting out 6-0 in the Big East Conference, Syracuse has since gone 4-6, falling to 10-6 in the conference and 22-7 overall, while Louisville improves to 12-4 in the Big East and 24-5 overall, with this being their fifth-straight victory.
Orange junior forward C.J. Fair led all scorers with 19, making nine of his 20 attempts in the 58-53 loss.