Carter-Williams made the most of the jump from fourth to first by leading the Big East Conference and the entire country in assists per game through much of this past season.
He also assisted in giving the offense more opportunities, with a steal-per-game average that was also among the nation's best.
The young guard ended the 2012-13 campaign fifth in assist average (7.3) and fourth in steals average (2.78) among all players on any of the 349 NCAA Division I men's basketball schools.
He started all 40 games for the Orange, helping the team to a 30-10 record.
Carter-Williams leaves on the heels of a run to the Final Four, Syracuse's first in a decade.
"Michael has informed me of his intention to enter the NBA Draft," said Boeheim, via a press release by Syracuse University Athletics. "He's coming off a tremendous season and we appreciate all he's done for Syracuse basketball. We wish Michael the best of luck as he pursues a pro career."
Carter-Williams shared via Syracuse University Athletics, "I want to thank Coach Boeheim and all the coaches for the amazing experience I've had playing basketball at Syracuse. I also want to thank my current and past teammates because if it wasn't for them I wouldn't be able to chase my life-long dreams. In addition, the fans, who have been unbelievable from the moment I got here. I'll always be a proud member of the Syracuse program."